Nonequivalent Binding to Human Methemoglobin
نویسندگان
چکیده
منابع مشابه
Evidence for nonequivalent binding sitesin human methemoglobin.
On the basis of nuclear magnetic resonance spectra, Davis, Charachc, and Ho (1) have recently suggested that the heme groups of the a! and /3 methemoglobin chains are not equivalent. Gibson, Parkhurst, and Geraci (2) have reported biphasic kinetics for the reaction of methemoglobin with a variety of iron-coordinating ligands. These results were also explained assuming nonequivalent heme groups....
متن کاملEvidence for Nonequivalent Binding Sites in Human Methemoglobin*
On the basis of nuclear magnetic resonance spectra, Davis, Charachc, and Ho (1) have recently suggested that the heme groups of the a! and /3 methemoglobin chains are not equivalent. Gibson, Parkhurst, and Geraci (2) have reported biphasic kinetics for the reaction of methemoglobin with a variety of iron-coordinating ligands. These results were also explained assuming nonequivalent heme groups....
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The characteristics of manganese and iron binding to human apotransferrin (apo-tf) have been investigated and compared in this study. Both metal ions were taken up by human apo-tf and formed complexes, with the maximum absorbances observed at 410 and 340 nm for manganese-transferrin (Mn-tf) and 465 nm for iron-transferrin (Fe-tf). Addition of manganese (1.5 µg/ml) to the reaction mixture contai...
متن کاملManganese and Iron Binding to Human Transferrin
The characteristics of manganese and iron binding to human apotransferrin (apo-tf) have been investigated and compared in this study. Both metal ions were taken up by human apo-tf and formed complexes, with the maximum absorbances observed at 410 and 340 nm for manganese-transferrin (Mn-tf) and 465 nm for iron-transferrin (Fe-tf). Addition of manganese (1.5 µg/ml) to the reaction mixture contai...
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The volume changes for the binding of various ligands to metmyoglobin and methemoglobin have been determined from the effect of pressure on the binding constants (for metmyoglobin) and by direct dilatometry (for methemoglobin). The volume changes associated with the binding of cyanide and azide ions to methemoglobin are pH-dependent. The volume change for the binding reaction is evidently affec...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1971
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)45924-3